What About Peptides?

Yesterday I had a patient, a medical doctor, who asked me about peptides. She asked whether I knew if my patients are using them. She was not the first person asking me about peptides. If you asked someone about peptides a few years ago, it would probably not ring any bells. Now, peptides is the latest buzzword in wellness and longevity.

Earlier this year, Singapore authorities warned against peptides sold online to help one grow muscles while helping with weight loss.

BPC-157 (body protection compound, or more famously known as the Wolverine) has been circulating around gyms and fitness spaces ever since fitness influencers like Joe Rogan touted its benefits. The muscle recovery effects are so popular that people have even injected their dogs to support their dog's health. Others are using a number of different peptides to improve cognition, longevity, sleep duration and revive sexual libido.

Peptides do occur naturally in our bodies. A peptide is a short chain of amino acids (which are building blocks for proteins), usually 2 to 50 amino acids linked together by chemical bonds called peptide bonds. If amino acids are individual lego bricks, and you put a few of them together, they become a peptide. If you link more than 50 of them, you build a protein. Since they are smaller, they are more easily absorbed by the body than full sized proteins.

While proteins are best known for building muscles, they have other important functions. We have millions of natural peptides in our bodies. Peptides act as messengers throughout the body. They regulate hormones, regulate inflammatory responses and boost our immunity systems. 

Since they are so versatile, artificial versions of peptides are used in medicine. These are lab grown chains of amino acids that mimic fragments of natural peptides. Insulin and GLP-1 (Ozempic and Wegovy) are 2 well known examples of FDA (food and drug administration in USA) approved synthetic peptides.

In late July 2026, the FDA voted to add 6 popular peptides to an approved list. BPC-1, KPV, TB-500, MOTs-C, Epitalon and Semax. Pharmacies in USA are allowed to use these peptides to make custom medications.

BPC-157 was approved as a treatment for ulcerative colitis, an inflammatory bowel disease. It is a synthetic peptide derived from a protein in human gastric juice. Very popular among athletes and gym rats after animal studies show that it could help heal fractures, tendon ruptures and ligament tears as well as reduce knee pain. However, these benefits are not confirmed in human studies. Almost entirely anecdoctal evidence from athletes self reporting faster recovery.

TB-500 is another trending peptide among athletes. This peptide was originally marketed for veterinary use in race horses and greyhounds. It has been marketed online for helping with tissue repair and regeneration, improving flexibility and boosting the immune system. Similar to BPC-157, TB-500 is promoted for healing muscle injuries, treating chronic diseases and inflammation. Human research is still lacking.

KPV is a peptide made of 3 amino acids, lysine (K), proline (P), and valine (V). A 2007 animal  study found that it can be a therapeutic agent for inflammatory bowel disease. Most research has been conducted in labs on mice. Another 2017 study tested a topical  KPV on human cadaveric skin  and found that it did not permeate well through skin and "could limit the systemic toxicity of KPV applied topically to the skin."

MOTS-c is created from mitochondria DNA to help with obesity and osteoporosis. Again, most findings have been limited to animal studies. 

Semax is a synthetic peptide developed in Russia and studied for its effects on the brain, including its effects on Alzheimer's disease. Evidence in humans remain limited. The FDA is evaluating how it can treat migraines, cerebral ischaemia and trigeminal neuralgia.

Epitalon is a pineal polypeptide extract from cattle and a 2025 study demonstrated high (or long) telomere lengths which are associated with longevity. Researchers are checking if they can improve sleep by increasing melatonin production and for insomnia treatment.

I think some people trying peptides may have exhausted conventional options and are bypassing quality checks if they buy and self administer based on information off social media. Others may want a 'short cut' to achieve their weight loss or training goals.

The world of synthetic peptides may be promising for sure, but there are dangerous side effects and some may even cause cancers. Do your research if you really want to try some of these peptides. Be aware of the side effects before you give them a go.

Reference

Mayfield CK, Bolia IK, Feingold CL et al (2026). INjectable Peptide Therapy: A Primer For Orthopaedic And Sports Medicine Physicians. AJSM. 54(1): 223-229. DOI: 1177/03635465251357593