Perhaps We Got Lactic Acid All Wrong

Remember the last time you pushed yourself way too hard while exercising? The buildup in lactic acid feels like a sharp, intense burning sensation in your working muscles. Your muscles feel really heavy, you quickly fatigue and you suddenly lose strength. This feeling goes away rather quickly when you slow down or stop.

What if we misunderstood what lactate (or lactic acid) is all this while? What if lactate does not slow you down but is actually a nutritional super fuel?

Yes, lactate has been accused to be the culprit behind behind 'burning' legs previously, but is now thought to be endurance sport's next nutritional breakthrough. 

Yomif Kejelcha used lactate (Spanish brand Sanat Madre's Lactate 60) while finishing 2nd and also clocking sub 2 hours in the London marathon earlier this year. In fact, Tadej Pogacar has been trialing a Enervit 'lactate gel' (a gel with lactic acid)  since 2024 when he won the Tour De France for the 3rd time. Pogacar recently won his 5th Tour De France this year.

Tadej Pogacar using Enervit's C2:1Pro Lactate Gel

So what are these new lactate gels and what is the science behind them? I was skeptical as I have been taught that lactate was the 'enemy', a by product that is responsible for burning legs and fatigue, not as a potential fuel source.

Going into Pogacar's jersey pocket

It all started in 2020 when Basque researcher Aitor Viribay first documented how 120 grams of carbohydrates an hour during exercise ignited the carbohydrate boom that was credited with helping cyclists, runners and triathletes going much faster. Viribay found that consuming more carbs promoted higher lactate availability in the body and thought that perhaps they can bypass the carbs and go straight to lactate utilization instead.

The original 'godfather' of lactate is Professor George A Brooks whose Lactate Shuttle Hypothesis (LSH) in 1985 completely overturned the old belief that lactate (or lactic acid) is a "toxic waste product" of anaerobic metabolism, but an important energy source. 

When you exercise really hard, your fast twitch Type IIb muscle fibers produce lactate through glycolysis - the breakdown of carbohydrate. Brooks found that lactate does not just build up and fatigue, but is actually 'shuttled' (or transported) to slow twitch Type I muscle fibers, the heart and even the brain where it is converted into pyruvate and used to generate energy through aerobic metabolism.

Lactate also goes to the liver, where it is converted into glucose via the Cori cycle (a metabolic pathway where the liver and muscles work together to recycle energy during intense exercise). This newly formed glucose can be released into the bloodstream to help replenish energy supplies for working muscles or stored as glycogen when demand from working muscles is less.

The lactate does build up when exercising hard, and at some point the body cannot clear or reuse it, but it is the associated rise in hydrogen ions that slows you down and not lactate. 

This Lactate Shuttle Hypothesis by Prof Brooks provides the physiological foundation for Viribay's ExoLactate Gel (40 grams carbs with 1:1 ratio of glucose to fructose and 5 grams of lactate) and Enervit C2:1Pro Lactate Gel used by Pogacar and UAE Team EmiratesXRG- cycling team.

The gel works by sidestepping several metabolic steps so users enjoy an extra energy boost quicker by bypassing the glucose and frutose intestinal transporters at the heart of those 120 grams/ hour studies. Lactate is absorbed through a different transporter called monocarboxylate or MCT1.

Athletes that have reached a carbohydrate ceiling now has the potential of adding a complementary lactate energy boost without the 2 substrates (glucose and fructose) competing at the gut wall. One can then go faster for a longer time frame.

And there is more. Lactate is also a 'lactormone', a signaling molecule which kickstarts a variety of physiological responses to help the body adapt and grow back stronger. High lactate cranks up mitochondrial biogenesis (growth). 

Mitochondria are our cells' energy powerhouses. So more mitochondria means improved stamina, reduced fatigue and improved performance. 

It also means better cardiovascular function, insulin sensitivity and overall metabolic efficiency. This may even have implications beyond sports as increasing research links lactate to health and diseases. Ringer's lactate is already used in hospitals used to treat patient's low blood volume from trauma, surgery and burns. Gut microbiota that is more exposed to lactate from exercise are also healthier.

What about having a product that can mimic an exercise dose for someone who cannot move is a huge health potential. This is called 'exercise mimetics' where a drug mimics the biological effects without actually exercising. Kind of like a much healthier version of GLP-1 (Ozempic and Wegovy).

Will I try these new lactate gels? I am keen to try, but my first question is how they taste and what is it going to do to my stomach as gastrointestinal issues are one of the biggest concerns for endurance athletes when trying something new.

Will lactate gels offer similar breakthroughs similar to the high carb fueling trends we have seen? Is it for pros only or can most of us mortals also use them? You should already be training, sleeping and eating well, fuel correctly before exercising for best results, prior to trying. Those are the true pillars of performance.

Reference

Viibay A, Arribalzaga S, Mielgo-Ayuso J et al (2020). Effects Of 120 g/h Of Carbohydrates Intake During A Mountain Marathon On Exercise-Induced Muscle Damage In Elite Runners, Nutrients. 12 95): 1367. DOI: 10,3390/nu12051367.

Exolactate's version