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Picture from Cyclinguptodate.com |
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Pogacar and Vingegaard |
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Picture from Cyclinguptodate.com |
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Pogacar and Vingegaard |
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Picture from Motherwellmag |
By the time they turn 13, their social anxiety levels are significantly higher than boys. If untreated, this may lead to poor mental health and interpersonal relationships. Academic and work performance later in life may be affected as well.
The article was just published on 300825 in the Research On Child And Adolescent Psychopathology. The Straits Times also published an article on it on 010925.
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ST 010725 |
Just after I came across the newspaper article, I remembered a recent study by Lundgren et al (2025) on how physical activity during certain periods can protect children from developing depression, anxiety and addiction. Their study was based on a large group of Swedish children followed from birth until their 18th birthdays. The long time frame allowed comparison between parent-rated levels of activity to diagnoses from a national registry. This is to eliminate pre existing issues that caused low activity levels or transient dips that were interpreted as social anxiety issues.
The study involved 17,055 children, who were born between 1997-1999. The parents had to rate various aspects of their child's health at 5, 8 and 11 years. Activity levels were tracked separately for school days and non school days. Participation in organized sports were tracked at 11 years and reported in hours per week.
The authors found that physical activity (reported by parents) declined from 4.2 to 2.5 hours each day between 5 and 11 years of age. Analyses showed that boys and girls had different outcomes and patterns.
Time outdoors showed no protective associations while participation in organized sports at 11 years of age showed significant protective effects on anxiety and addiction for both boys and girls and on depression for boys. The authors concluded that his study provides evidence that physical activity and participation in organized sports may have protective effects against several adolescent mental health diseases.
Possibly policymakers working to control vaping in Singapore could use this information?
Access to the articles at the links below.
References
Lundgren O, Tigerstrand H, Lebena A et al (2025)Impact Of Physical Activity On The Incidence Of Psychiatric Conditions During Childhood: A longitudinal Swedish Birth Cohort Study. BJSM. 1:59(14): 1001-1009. DOI: 10.1136/bjsports-2024-108148
Tng GY, Law ECChen HY et al (2025). Developmental Trajectories Of AnxietySubtypes From ChildTo Early Adolescence: The Role Of Parenting practices And Maternal Distress. Res Ch Adoles Pysch. DOI: 10.1007/s10802-025-01364-4
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Just when I'm reading about Ultras |
So I was very surprised when I came across a poster presentation that suggested that those who do high volume ultra marathon and marathon running may actually have an increased risk of advanced pre-cancerous colon lesions. The New York Times wrote about this too.
Researchers had 100 long distance runners ranging from 35 to 50 years who completed at least 2 ultramarathons (> than 50 km) or 5 marathons. These runners underwent screening colonoscopies, with all polyps reviewed by a team of oncologists, pathologists and gastroenterologists.
They were found to have polyps (> 10mm with tubulovillous features) that were more likely to turn into cancer compared to the general population (40-49 years old). 15 percent of the 100 runners had advanced adenomas. This was greater than 10 times higher than the benchmark. 39 runners had at least 1 adenoma of any type. Prevalence in the matched general population was just 1.2 percent.
Most cases happened in runners with very high training exposure (pictured above), multiple ultramarathons or completed more than 15 races. There were even a few cases of high grade dysplasia, just 1 step away from colorectal cancer.The researchers' hypothesis was that due to extremely high volume distance running, this leads to repeated low blood flow to the gut leading to chronic injury and inflammation. This can repeatedly injure the stomach lining. This recurring pattern may then accelerate carcinogenic changes that lead to the development of pre-cancerous adenomas.
Moderate exercise does lower systemic inflammation, but ultra marathon training can increase inflammation in the gut made worse with frequent high volume racing. This worsens during intense exercise in the heat. Since chronic gastrointestinal stress impairs absorption of fibre and micronutrients that normally protects the colon, their findings may be reasonable. More so if recovery isn't adequate.
The difference compared to the normal population does cause some concern. However, do note that this is a relatively small study done only in 1 location. There is no proof of causation, genetics, nutrition and other lifestyle factors that may also play a role.
For most of us runners, running is protective against colon cancer, and does not increase our risk to it. I do not have any patients who run >2 ultra marathons or more than 5 marathons a year. If they do, then their risk profile may (emphasis on may) be higher.
So if you do log mega mileage, race often and are concerned about your cancer risk, it may be wise to get colon cancer screening particularly if you have persistent gastrointestinal symptoms.
Do wait for the full peer review study to be published before making any final conclusions.
Reference (for the abstract)
Cannon TL, Bonomelli S, SwainWR et al 92025). Risk Of Pre-Cancerous Advanced Adenomas Of The Colon In Long Distance Runners. J Clin Oncology. 2025 ASCO Annual Meeting. 43(16) suppl. DOI: 10.1200/JC0.2025.43.16_suppl.3619
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Let's go for a walk |
Previous studies have shown that walking speed is a significant predictor of life expectancy in older adults. Pooled results from 9 studies involving 34,000 adults aged 65 and older showed that walking speed was significantly associated with lifespan. Men with the slowest walking speeds at age 75 had a 19 percent chance of living for 10 years compared to those with the fastest walking speeds who had 87 percent chance of survival.
Another study found that even amongst healthy adults aged above 65, participants with slower walking speed were 3 times more likely to die of cardiovascular disease compared to those who walked faster.
Did you know that if you are a slow walker you may have a smaller brain compared to a faster walker? Research has shown that how fast you walk to the shops, MRT, or your local coffee shop can predict your chance of a heart attack, being hospitalised or even dying. Your walking speed can even reveal your rate of cognitive ageing.
As we age, these systems start to slow down. Studies show that walking speed is a significant predictor of life expectancy in older adults. This does not just apply to older adults as Rasmussen and colleagues (2019) found that even amongst 45 year olds, a person's walking speed can predict the rate at which their brain and body were ageing.
In that study (Rasmussen et al, 2019) had 904 subjects, all 45 years old born between 1972 and 1973 living in New Zealand. Their health and cognitive function were assessed regularly over their entire lifespans.
There was fairly huge variation in walking speed among the subjects. You would think that these 45 year olds would have similar walking speeds but some walked as quickly as healthy 20 year olds while others walked as slowly as much older adults.
The 45 year olds with slower walking speeds showed signs of "accelerated ageing" with their lungs, teeth and immune systems were in poorer shape compared to those who walked faster. They also had 'biomarkers' associated with a faster ageing rate such as higher blood pressure, raised cholesterol and lower cardiorespiratory fitness.
The slow walkers also had a weaker hand grip strength and found it more difficult to get up from a chair. Other signs of cognitive ageing include lower IQ test scores, worse memory test scores, processing speed, reasoning and other cognitive functions. MRI scans showed they had smaller brains and a thinner neocortex - the outermost brain layer which controls thinking and higher information processing.
Even the faces of the slow walkers were rated as ageing faster than the faster walkers!
The research suggests that the slow walkers' brains and bodies age at a faster rate compared to the quick walkers. There were already signs that these health differences were present from an early age as researchers were able to predict the walking speed 45 year olds based on intelligence, language and motor skills test taken when the participants were just 3 years old.
Wow, I am so surprised that there is a link between how fast people walked at 45 years old and their cognitive abilities all the way back to when they were 3 years old. Perhaps walking speed is not only a sign of ageing but a clue to lifelong brain health.
Reference
Rasmussen LJH, Caspi A, Ambler A et al (2019). Association Of Neurocognitive And Physical Function With Gait Speed In Midlife. JAMA Netw Open. 2:2(10): e1913123. DOI: 10.1001/jamanetworkopen.2019.13123.
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Picture from Truenorthwellness |
A new meta-analysis pooled results from 20 prospective cohorts thus investigating nearly 400,00 people (Weeldreyer et al, 2025). Participants were categorized by body mass index (BMI) as normal weight, overweight or obese. Their carodiorepiratory fitness (CRF) were measured by maximal exercise testing to determine if they were fit or unfit based on age adjusted VO2 max. This was to determine if BMI or CRF predicts mortality risk better.
This meta-analysis is different from earlier ones since it includes more women. It also has participants from a broader age range, geographic backgrounds and health status. Better statistics all round. Findings more generalizable and results more precise.
The reference group - normal weight and fit was compared to all other combinations. Compared to the reference group, those who were both overweight but fit and obese but fit, both groups had virtually the same risk of dying from any cause. About 4 percent lower and 11 percent higher respectively, which was not statistically significant. Being fit protected against being overweight and obese for all-cause mortality.
Not so good news for the unfit. Those who had normal weight but were unfit had a 92 percent higher all-cause mortality risk. The risk was similarly high for unfit and overweight (82 percent higher) and even higher for the unfit and obese (104 percent higher).
For cardiovascular disease mortality, the differences between weight categories were more pronounced. The fit but overweight had a 50 percent higher risk while those fit and obese had a 62 percent higher risk than fit individuals with normal weight. Note that neither was significant, although it meant that being fit protected one against the risk of dying from cardiovascular disease.
Now for those who were unfit for cardiovascular disease mortality, the numbers were not pretty, in fact they shyrocketed. 104 percent higher risk for normal weight, 158 percent for overweight and 235 percent for the obese.
In short, being unfit more than doubled mortality risk for many cases, regardless of BMI, while being fit can netralize the impact of carrying extra weight.
These findings show that BMI alone is a weak predictor of health and improving cardiorespiratory fitness can cancel out much of the risks associated with a higher BMI.
Perhaps BMI is not a good indicator. One may have a high BMI and yet be muscular and fit - the Amercian football players in the NFL have high BMI values. They are classified as obese, but they are actually very fit and muscular.
Should we be more concerned with increasing fitness levels over weight loss during public health awareness? There seems to be more emphasis now on weight loss and eating less processed food rather than increasing physical activity.
This study suggests boosting fitness levels should be at the top of the list, not just as a replacement for tackling obesity. Studies like this show that physical activity is definitely more important than diet for those who want to live to a ripe, old healthy age. Not to say that diet does not matter. But fitness is king. Perhaps our Ministry Of Health should angle some incentives?
Reference
Weeldreyer NR, De Guzman JC, Paterson C et al (2025). Cardiorespiratory Fitness, Body Mass Index And Mortality: A Systematic Review And Meta-Analysis. BJSM.59:339-346. DOI: 10.1136/bjsports-2024-108748
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Picture from Arabnews |
Well, while Singapore celebrates turning 60 on August 9th, 2025, a sprawling shopping centre in Dubai organized a "Mallathon" on the same day.
Back by the Dubai government, it aims to encourage exercise during the hottest month in United Arab Emirates (UAE). They make use of Dubai's giant malls which are otherwise empty at that time.
Runners can take part in organized 2.5km, 5 km and 10 km races at designated malls complete with podium presenattions and prizes.
One can also wait in line to use electric bikes that powered blenders to make healthy smoothies after exercising.
Perhaps our Singapore malls can do the same. To help revive our ailing retail and food and beverage scene.
Happy National Day Singapore!
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See how cheap they are |
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2 Pirelli tubes on the left |